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Evidence-Based Innovation

Advancing the Science of Healing

Our field is dedicated to the highest standards of clinical data and curated research. May we bridge the gap between ancient wisdom and modern rigorous evidence to redefine mental health care through psychedelic-assisted psychotherapy.

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Psychedelic Therapy and the Role of Music: A Scoping Review of Quantitative Evidence on Subjective and Objective Outcomes

This review underscores the critical role of music in shaping psychedelic experiences and therapeutic outcomes.

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Human Brain Changes After First Psilocybin Use

2026. Increases in cognitive flexibility, psychological insight, and well-being are seen at one-month. 

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MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial

MDMA-assisted therapy provides highly effective treatment for PTSD, showing significant safety and clinical benefits.

Research & Articles

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An international mega-analysis of psychedelic drug effects on brain circuit function

This study provides the most comprehensive synthesis of psychedelic brain action to date (2026)

The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world

Scale to measure connectedness to self, others, and the wider world, especially before and after psychedelic therapy. 

How Psychedelics Affect the Brain

Ongoing research is examining how psychedelics like psilocybin affect the brain and may treat mental health disorders. Recent studies suggest controlled doses may help relieve depression, anxiety, and PTSD.

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Clinical Success

Participants showing significant reduction in PTSD symptoms after three sessions of MDMA-assisted therapy in phase 3 trials.

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Sustained Healing

Follow-up data indicates that clinical improvements remain stable for at least one year following the treatment protocol.

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Therapeutic Alliance

High scores in patient-reported therapeutic alliance, correlating with the deep relational work facilitated by psychedelics.

“Just because something isn’t a medical model doesn’t mean you can’t have mental health benefits” -Korthuis 

Study finds sustained benefit for people using Oregon psilocybin services

OHSU-led research is the largest study of psychedelics outside clinical trials

The study enlisted 346 people who joined licensed facilitators for a single session using psilocybin between November 2024 and June 2026. Participants reported their state of mind at baseline, one week, one month and three months after single psilocybin sessions at 24 licensed service centers in Oregon.

Participants reported their experience through a web-based portal, with 90% continuing to do so through three months. Key findings:

  • At one month, 91.5% felt they benefited and 64.9% ranked the experience among the 10 most meaningful of their life.

  • At three months, participants reported decreased moderate-to-severe symptoms of depression, anxiety and PTSD. They also reported improved mental well-being and life satisfaction.

  • Few reported their experience as harmful, although four who used psilocybin for the first time experienced adverse behavioral reactions that required medical attention. No participants reported a serious event related to their physical health.

They offer a  free and extensive library of articles from health professionals and the psychedelic community!
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